Nattokinase Side Effects and Dangers

 

There are no proven side effects of nattokinase. Which is great news if you want to use this incredibly powerful enzyme to keep your blood pressure normal or if you have problems with your circulation like I do (I wear a compression stocking on my legs to send the blood back around my body). At one time I was prescribed warfarin, and I am really glad I was able to finish taking this dangerous medication.

Although I wear compression stockings to keep my blood flowing, my blood vessels still need assistance in helping my blood flow freely. This is one of the reasons I take nattokinase, twice daily.

dangers of nattokinaseIf you are currently prescribed long term warfarin, you should know that you are at a higher risk of a brain hemorrhage (please do further research or contact your doctor right away, if this is new information to you). You may also be surprised to learn that warfarin, although a stroke preventing drug, may actually cause a different type of stroke, called a hemorrhagic stroke (read about it here).

The great news is though, that warfarin is being phased out in people who are at high risk of arterial fibrillation (symptoms range from fainting, dizziness, palpitations and congestive heart failure) It is being replaced (or advised as an alternative) by newer, safer drugs. Although approved by the FDA, my reservation with this is really, how safe are these drugs in the long term. Remember, warfarin was also safe to use when it was first released.

Time will tell, and this is certainly food for thought. But it is just another reason why the natto enzyme could be more readily used or even prescribed to keep your blood thin (for certain patients anyway). And certainly used as protection against coronary heart disease.

When Should You Not Take Nattokinase?

Is the nattokinase enzyme safe to use? Yes, if you are a healthy person with no blood disorders or if you are pregnant and then it is dangerous to take it. As we’ve discussed, there is not enough known about the effects (or even side effects) of this enzyme on pregnant woman, or on the fetus itself. So if you are pregnant, either see your doctor before taking it, or refrain from taking raw natto or any kind of nattokinase supplement during your term. It’s always better to be safe than sorry.

Also, if you have any kind of injury or trauma, then the best advice is not to take this enzyme. We know that nattokinase helps to thin the blood. So if you have an injury that is bleeding externally or internally like a stomach ulcer, then you should exclude it from your diet or supplement regime.

The same also goes for any kind of surgery, even dentistry type surgery. Any time your body is at risk of losing too much blood, is a good time not to take nattokinase.

You should also avoid taking the enzyme if you are currently taking any kind of blood thinning treatment like warfarin, aspirin, heparin and ibuprofen (note that some of these are normally used for pain relief, but bare them in mind if you consider taking nattokinase). Your body does not need two agents acting in your cardiovascular system reducing it’s ability to form clotting as this could stop your bodies natural process of repairing itself.

However, your body does need an ability to coagulate (if you cut yourself, for example) and if your blood is unable to clot then you would lose too much blood. Also, if you encounter a tiny hole in a blood vessel, your blood must be allowed to clot to repair these holes.

And if you currently take any kind of anti-coagulant medication, you should not use nattokinase as the combination of both of these can cause you serious bruising from even the slightest touch of your skin.

Nattokinase also lowers blood pressure, so if you are anemic or generally suffer from low blood pressure, then you should again, not take this enzyme as it will further reduce your blood pressure, causing you nausea, dizziness and the possibility of you passing out.

What Could It Do to You if You Did Take It?

So if you do want to take it and want to know the correct nattokinase dosage, please read the article that link points to.

And to conclude, what are the potential side effects of taking nattokinase.

  • Blood unable to clot (if used with prescription medication)
  • Bruising and bleeding
  • Severely reduce blood pressure
  • Nausea and dizziness

Again, if you are pregnant or are unsure if you should take nattokinase, always consult your doctor.

Common sense should prevail when using nattokinase. It might be 100% natural, but it can seriously affect your blood system, particularly if it is used with other medication. You may think it’s only a little tablet and because of what it says on the tub, that it is perfectly safe. But it is a very powerful enzyme, which can work wonders for the average person who wants to regulate their blood pressure or help their blood flow easier. But if you are taking other anti-coagulant medication, it may be harmful to you. Always consult your doctor before taking nattokinase in these cases.

nattokinase

 
About Andy James

Andy is a health and wellness enthusiast who has a great interest in the cardiovascular system, and more specifically blood circulation. He has suffered with poor circulation for many years, hence why he has to wear a compression stocking on his left leg. But since he was introduced to nattokinase by a colleague, and started taking it on a daily basis his circulation is circulation flows more freely and he has got a lot of pain relief from this incredible little enzyme. You can find out more about Andy on his Google+ profile, where you will find his other sites and projects.

Comments

  1. G bridges says:

    Can nattokinase be taken for blood thinner in place of aspirin with atrial fib? Also with Hawthorne, Cheyenne, gingko, krill oil turmeric, ,etc.?

    • I would not like to comment G. Bridges. I hope you can appreciate that I am a health enthusiast, not a medical professional. My recommendation would be to speak to your own doctor about this, because nattokinase does thin your blood and lower blood pressure. So I am not sure if it would be wise to use nattokinase in your case.

  2. Riccardo Pacini says:

    I am a 74 years old, heterozigous to factor 5 Leiden, I am healthy now, but I had a stent in the heart implanted 4 years ago. I am being prescribed some blood pressure medication, metoprolol, pravastatin sodium for cholesterol, and a full aspirin daily. I will check with my doctor and cardiologist in January if I can substitute nattokinase, or natto paste for the one daily aspirin, and the blood pressure medication. I wonder if my doctors know about this natural product? I have not yet located the enzyme supplement or the natto paste in the Denver Co area, I may try on line. Thank you RP

    • Thanks for your message, Riccardo. Checking with your doctor before you decide to swap nattokinase with one of your aspirin tablets is best. They do not mix. I’m sure your doctor has heard of nattokinase, if not please refer him to our site and the links contained therein.

      To obtain nattokinase, please come back to our site at any time and just click one of the images which will take you to the page you need.

      We wish you the very best. And please contact me again if you require further information.

      Andy

  3. I have a friend that is taking warafin for a clot in her leg after a knee injury it runs from her ankle to mid thigh she has been taking it since Oct gets her blood checked about every two weeks her hair is falling out more than before sore muscles manly upper arms and she h as ridges on her toenails and finger nails we are looking to find something that isn’t rat poison is nattokinase an option?

    • Yes John, Nattokinase is an option. I take nattokinase for a similar reason – blood clot in my left groin, which left me with poor circulation, bruising and a lot of swelling. My symptoms are virtually non-existent now, although regular exercise still plays a part in therapy.

  4. Thanks for getting more word out about Nattokinase!!
    I’ve been taking nattokinase for several years now. I am hetro/combo for mthfr and also have protein s deficiency. I have not never had a clot I’m 54 yrs and have been taking it around 6 yrs. before that I took asprin.
    Every doctor I have talked to has no idea what it is, and its not FDA approved for breaking down blood clots nor most likely ever will be
    . There are people taking nattokinase with Coumadin (my mother is one of them). Natto the food has a good supply of vit k which is very much needed but is a problem with Coumadin (warfarin). The nattokinase pills do not contain vit k at least the ones I’ve taken don’t. My mothers pt/inr has actually stabilized more sence she started taking this. She takes ( 1 )100mg pill twice a day away from food. She still will not give up the coumidin because without it her pt/inr reading is 1 to 1 1/2 which is normal but not in the 2-3 therapeutic range that Coumadin keeps it in. Coumadin does not disolve clots, it thins your blood so that it isn’t as likely to form a clot and when a clot is there already, it keeps it thin (if you can keep the numbers right) giving your bodies natural clot buster (plasmin) more time to do its job.
    Nattokinase works like plasmin and disolves unnecessary clots without breaking off chunks that go to heart brain or lungs. I would like for my mother to be completely off Coumadin but she’s still afraid to. She does take a low dose at least though and getting her pt/inr checked weekly makes her feel safe.
    She has had many dvts, and several embolisms and hasn’t had any after taking Coumadin so she’s afraid.
    She has had mini strokes/brain bleeds after Coumadin and prior to nattokinase. Her mother died on coumidin with a filter in her lungs to keep clots out as she to had many dvts and a couple of embolisms.
    My grandmother also had very swollen ankles and later her legs which would ulcerate and weep fluid. My mother had started having the same issue and was diagnosed with lymphedema which meant compression stockings and trips to the clinic daily for lymphatic massage.
    Her incurable lymphadema is gone now which the only thing different is she no longer takes Norco for her rheumatoid pain or that the nattokinase also took care of this by giving more blood flow to the feet. In all fairness she was takeing the nattokinase for almost a month when her ankles swelled up again. She than quit her pain med and they went down on their own.
    They do have other test that if someone wanted to get off Coumadin and on to nattokinase medically supervised you could but it would be hard to convince a doctor to take you off of a fda approved drug and put you on an enzyme that most have never heard off and order what would be a unnecessary test and bill insurance. Nattokinase will most likly never be approved because it can’t be patented. This is the only way a drug company can get back the money that the testing and proving up cost which is millions.
    Canada recently stopped the sell of nattokinase. I guess if the US does the same I will be making my own natto food product and consuming it.lol
    It’s also recommended not to take it before or after surgery. I stop taking it 24 hrs before and resume 24 hrs after. I am recuperating from back to back knee surgery and was much more worried about a blood clot due to inactivity vs hemorrhaging. When I first started taking this I noticed that my blood was a little thin. I have horses and cut myself frequently working with them. I also was drinking 2 to 3 drinks a day and would take 3 asprin when I had a headache.
    IMO I think its better not to mix asprin etc when you first start taking it but to give your body time to adjust. When I got a blood test before natto, my blood would almost become a solid clot in the tube and the nurse would always comment about it. It doesn’t do that now and I’m also a lot easier for them to draw blood from. When I cut myself I bleed much more than before but its normal like I’ve seen others bleed. Before my second surgery I fell and wacked my nose on a metal pipe hard.it bled profusely and had small fracture but it stopped bleeding in couple minutes which from what I’ve seen before seemed normal .Anyway I hope this helps someone. I’m not a doctor nor work in bio chemistry….just a woman with a family with blood clotting disorders :)

    • Hi Brenda,

      Thank you for sharing your story on our site. I think anyone reading your message can easily see how beneficial nattokinase is to them if they suffer the same kind of problems as you and I (and your mother). Yes, it is a shame that this enzyme isn’t FDA approved, as it could help so many more people than it already is – without the nasty side effects of warfarin.

      I wish you the very best of health.

      Andy

  5. cathy sundheimer says:

    hi ? about nattokinase. I have fibrin tissue in my liver which has grown to like 4 by 4 inches at times I have lots of pain . i also have diverticulitic. if i take aspirin i notice more bleeding from rectum. my natural doctor wants me to take nattokinase to dissolve the fibrins and i also have severve flem build up at my throat which is quit tough to deal with. which this nattokinase is also to dissolve the flem. do you feel this is a good supplement to take care of these issues? my natural doctor wants me to take full bottle at one time. i am a little scared to take 100 pills at once. is this safe? what is your suggection? thanks…

    • Hi Cathy, thanks for your message.

      Its great to hear of a doctor recommending nattokinase, in fact its pretty unusual in my experience. Personally, I think taking a complete bottle of nattokinase is completely ‘barmy’, your body could not cope with that much and it would definitely affect your blood system in a detrimental way.

      The most I ever took was one capsule than the recommended dose. This was enough to thin my blood, so that it was problematic, ie when I cut myself, my blood took too long to form a clot. Regarding your phlegm issues, I think serrapeptase would help you. You can take nattokinase and serrapeptase together, but if you do, you should refrain from taking aspirin or anti-coagulants. Please refer to our disclaimer at the bottom of the page, I am only a health enthusiast not a medical professional.

  6. Madaliene Souza says:

    I’m seeing Dr. Slavin homeopathic and has me on nattokanise, i am so glad I read your article i have been taking ibuprofen and didn’t know you shouldn’t…please send me emails,i enjoy reading…my fibrinigin was high that’s why she put me on it…thks again

    • It is actually great to hear that your doctor has recommended nattokinase, instead of drugs. Come back and let us know how nattokinase is helping you in daily life. Thanks for your comment.

      Andy

  7. I have been taking natto with Serrapeptase for almost a year, 6 pills a day of Nattokinase alone. It is supposed to help with the pain from endometriosis and adhedsions, both of which I have. I also take 4 advil at a time, though I have been trying to cut back. I thought the enzymes were helping, but the last 3 weeks I have been in constant pain and nothing helps. I think I need to quit taking the enzymes, this article scared me. I was researching side effects and both enzymes are listed as blood thinners. The mega doses I’ve been taking, combined with lots of advil is probably not safe.

    • Hi Angela, sorry to hear of your problems. You are quite correct about taking nattokinase and advil together, this is very dangerous as your blood will be way to thin. If you were to get a serious cut, or worse, the clotting process would be drastically affected.

      Also, taking too much advil will likely affect your digestive system, detrimentally. I would advise to seek your doctors advice and explain to him/her about the amounts of both substances, which you’ve been taking.

      I am a huge advocate, as you will have read here, of nattokinase and I hope that once you’re over this ‘blip’, you will be able to take it again, as I do, to protect your blood system, and more.

  8. Hi Andy. I have a 17 yr old daughter who was diagnosed with an unprovoked clot this past January. She was in hospital for a week on heparin and then home on lovenox for 2 mos and now on Coumadin till July. She has swelling still in her leg, wears a short stocking daily and long one for travel. We have been researching her long term outcomes as she is very active in sports. Hockey, volleyball and skiing. The Nattokinase looks great. Have your ever known someone so young to take. We are going to her specialist in3 weeks and hope to bring this information to him. Anxious to hear your thoughts.

    • Hi Kris,

      Thank you for contacting us, and I am sorry to hear of your daughters clot. Glad to hear she’s wearing the stockings, my own are a permanent fixture because I sit at my desk for up to ten hours a day! I think if I had an active job, I would not need to wear them so much – just for long journeys etc.

      I have not come across information pertaining to nattokinase and children, I’m afraid. However, as there are no side effects, other than for someone who is already taking blood thinners, I don’t foresee problems for her. But that would be for you to decide with her doctor.

      One thing to be mindful of, is that because she is very active with sports, the inevitable ‘bumps and bruises’ from sports such as hockey, may worsen or cuts may take longer to clot and heal than normal, when using nattokinase.

      Sorry I could not have been more help, I wish your daughter (and yourself), the very best of health.

      Andy

  9. Tom Mckee says:

    Andy,
    I have tested positive for one copy of the G20210A mutation after suffering a PE. I am on warfarin for life. Do you know of anyone taking natto in lieu of warfarin to prevent DVT.
    Thanks.. Tom

    • Hi Tom, thanks for your message.

      I don’t personally know anyone, but I have read stories (I can’t remember where, sorry..) about people using nattokinase as a preventative. In an extreme case such as yours, I think you would need extensive discussions with your doctor about this, before making a decision. And maybe consider using krill oil as well as natto, as this too is a very good, natural blood thinner (if you would like more information on krill oil, please use my contact form and I will send you some information).

  10. lee anthony says:

    Four years ago I developed Afib. My doctors wanted to put me on prescription blood thinning medication. After much research, I decided to go with nattokinase and serrapeptase, the latter for clogged arteries. I assume it is working as I have not had any clots or strokes, or whatever the potential damage from AFIB can cause. Unfortunately, I developed an AAA anurisum and had to have a recent, June 11, 2014, open repair. A week before the procedure I stopped taking all supplements. While in the hospital, the cardiologist insisted on me taking coumadin, at least until August when they will try Ablation to fix the AFIB. I explained to him that I have been taking nattokinase, aged garlic exrtact, and serrapeptase. He had no idea about them and just looked at me and said, “Where are the studies to prove it works?” So, in order to have him release me from the hospital to go home I had to agree to take the coumadin. As soon as I got home, I switched back to nattokinase. However, I have now learned that it should not be taken prior to, during, or after surgery. So, it looks like I may have to take the coumadin, after all. I really don’t want to take that junk. My question is how long after surgery should a person wait before resuming nattokinase? I can’t find an answer to this question anywhere.

    • Thanks for your message, Lee. Sorry to hear of your troubles. May I first wish you a speedy and healthy recovery. I love your doctors near ‘denial’ of the benefit of nattokinase, but I guess that would be most doctors replies because they tend to rely on drugs! There seems to be varying opinions about timing. Prior to surgery, you are right – the blood must not be too thin. But post surgery, I’ve read from a week up to a month, to re-introduce it back to your system.

      The latter seems to contradict the recommendations for coumadin mind you, a month seems way too long. If I find any more information, I will repost it here for you.

      Andy

  11. Elizabeth Kenoyer says:

    I would like to take natural bloodthinners instead of the coumadin I now take. What supplements could I take along with coumadin and without coumadin under a doctor’s supervision, of course. I am trying to raise my INR naturally instead of increasing my dosage of coumadin. Please help. Thank you.

    • Hi Elizabeth, thanks for your message.

      Recommendations for natural blood thinners, are that you don’t take them if you are already taking coumadin. You risk blood becoming too thin, which is dangerous. Otherwise, nattokinase and serrapeptase together would be your best choice. Please understand that I am not a doctor, so you would need to discuss your options with your own doctor.

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