Serrapeptase Benefits

Finding an organic alternative to a harmful drug you can buy in a pharmacy, is a real plus for many people. And if you are anything like me, then discovering the powerful anti-inflammatory and pain relief effects that the super-enzyme serrapeptase has, it is a huge positive in your life.

Serrapeptase enzymes have wonderful benefits for cancer patients, they help improve and guard your cardiovascular health and when combined with nattokinase, the combination presents a huge problem for heart disease – protecting the blood system, breaking down deadly substances and fighting inflammation. Serrapeptase has fibrinolytic actions, which means it breaks down fibrin in the blood. Fibrin is a protein that when acting normally, aids normal blood flow and clotting. When it is not normal, the actions result in hypercoagulation (dangerous thickening of the blood) and the forming non cancerous tumors.

Note: We have put links to each section of this article to help you easily find what you are looking for.

Table of Contents

What is Serrapeptase?

silkworm Serrapeptase (also known as serratiopeptidase and serralysin) is a powerful nutritional and the principal anti-inflammatory protease (enzyme) in its class, ranking higher (for its healing properties) than other proteolytic enzymes like nattokinase and lumbrokinase, to name just two. Serratiopeptidase promotes a healthier inflammatory and immune system, supporting joint health, protecting connective tissues of the ligaments and tendons. It also helps your lungs and respiratory system to function more effectively, helping to promote your overall well-being.

Serrapeptase is obtained from the isolated bacteria, serratia E15. In its organic form this is found in the intestines of the silkworm, but it is also harvested through fermentation for commercial reasons. In its natural state, it is so powerful that the silkworm produces and uses this enzyme to escape its tough cocoon after it has turned into a moth. It melts away the hard coating of the chrysalis so moth can fly off and begin its new life.

What Are the Health Benefits of Serrapeptase and What is it Mainly Used to Treat?

  • Heart health
  • Throat infection
  • Ear infection
  • Sinusitis
  • Bronchitis
  • Laryngitis
  • Fibromyalgia syndrome (extreme stress and fatigue, including insomnia)
  • Varicose veins
  • Halitosis (bad breath)
  • Urinary tract infection (UTI)

That list is just some of the health problems that serrapeptase helps to treat. It is mainly used because of its natural anti-inflammatory properties, so it is used to relieve a wide range of pains and infections, from a sore throat to the pain suffered from the effects of arteriosclerosis (ASVD) – chronic inflammation of the artery walls, causing them to harden and thicken. The symptoms of arteriosclerosis are decreased blood flow, chest pain, possible arm pain and shortness of breath. In worst cases, heart attacks and even sudden cardiac failure/death has been reported.

Although arteriosclerosis can appear during childhood, most serious cases have been associated with in their mid to late forties. The problem is that when LDL’s (low density lipoproteins) are hindered, they cannot transport bad fats like cholesterol, triglycerides and phospholipids away efficiently enough, causing inflammatory thickening and damage to artery walls.

Prevention is always better than a cure, and we can see in the case of heart diseases like arteriosclerosis, it starts as early as childhood. Although at this point symptoms are not life threatening, its worth remembering that if someone’s lifestyle is poor, the risk of contracting heart disease is naturally quite high.

Protecting your heart health is vital, which is why serrapeptase is highly recommended in these cases.

There are also real life accounts of serrapeptase helping to clear catarrh and the mucus caused by the common cold and influenza. And ‘they’ said that they can’t cure the common cold! Women suffering breast engorgement and women with non cancerous cysts or growths in their breasts have also cured their symptoms.

Other health conditions that need further clinical studies and research on the benefits of serrapeptase:

  • Migraine
  • Other headaches
  • Asthma
  • Breast engorgement
  • Irritable bowel syndrome (IBS), Crohn’s disease & ulcerative colitis
  • Arthritis – rheumatoid and osteoarthritis

This list of health conditions is expanding all the time, as ordinary people like you and me report how this organic, immunologically proactive enzyme has helped them. And the more people that do come forward and express their honest opinions of serrapeptase, means that many more people in the future will benefit from it. The same is said for the benefits which nattokinase has to offer; the more people that know it works, shout about it, the more new people will know of its existence in the future.

How Does Serrapeptase Work to Treat Health Conditions?

Just like it breaks down the hard shell of the silkworm cocoon, serratio peptidase attacks dead cells, tissue and protein derivatives in blood clots, cysts and other inflammations, like hardening of the arteries (arterial plaque from atheroma – calcified swelling and inflammation). It gets to these crucially damaged areas of the body by attaching itself to a plasma protein found in blood, called ‘Alpha 2 macroglobulin’. Serrapeptase will only break down and absorb dead tissue – it is without side effects or the danger of affecting living tissue.

Serrapeptase also helps to dilute injury made fluids (pus), helping them to drain away from the injured area, which then accelerates the repairing and rebuilding of tissue. This incredible little enzyme does all this without damaging ‘good’ cells and living tissue, which means it is a powerful natural treatment for heart and blood related conditions. It can break down the bad stuff in your blood system, and just carry it away very safely.

Serrapeptase and Cancer

Firstly, lets clear up something very important relating to cancer and the effects of the serralysin enzyme. It is not a cure for cancer. But, studies have reported reduced swelling (in breast cancer), reduced pain relating to cancer and serrapeptase has been shown to prolong remission, helping cancer patients to live longer.

It does this by breaking down the fibrin coating of the cancer cells, exposing them to anti-bodies of the immune system which then do their best at neutralizing bacteria and bad cells.

Are There Any Side Effect to Serrapeptase?

We’ve discussed the benefits of taking this supplement, now lets talk about the dangers this enzyme might have on your body (if there are any).

What do we know so far about this isolated bacterium, serratia E15? Well, we know that it attacks dead cells and we know that it dissolves blood clotting. It is an anti-inflammatory that dissolves cysts in women’s breasts, it is a natural treatment for infections such as bronchitis, cystitis (UTI) and it is good for your heart health (reducing blood pressure and hypertension) and scales away the fibrin that coats cancer cells.

But, even though studies have been conducted and serrapeptase has been deemed safe to use for most people, as with any medication or supplement, a small minority of people may experience some kind of consequence that might put you off taking it. So although only a hand full of cases have been reported, they are definitely worth investigating and understanding, so you can make an informed decision about serrapeptase before taking it.

One person expressed that not long after ingesting their enzyme supplement, they experienced an upset stomach and vomiting. Not wanting to rule the supplement out of their diet after one trial, they did try taking a further tablet days later but experienced the same side effects.

Important: I have read the safety information on several brands of serrapeptase and authoritative medical sites, and all of them warn not to take it if you are prone to gastrointestinal problems and stomach upsets. Particularly if you are elderly.

So you must wonder if this person was either one of those people who does suffer tummy upsets and was perhaps elderly, or even neglected to read the label and therefore should not have been taking the supplement in the first place.

Another person (aged 70+) reported how they developed a cough after taking serrapeptase, which aggravated their lungs. Again, an authority medical website which I find very informative declares that this enzyme could cause mucus secretions. But as with gastrointestinal problems, this was very rare. Again, notice their age.

Conclusion About Taking Serrapeptase

  1. On the scale of things, serrapeptase hasn’t been around for long in the United States (only just over ten years), but the Japanese have been using it for many hundreds of years. Plus, Doctor Hans Alred Nieper, a German physician, used this protease enzyme until the end of his career (before passing in 1998), to treat patients suffering from an arterial blockage. Just to give you an idea of how long serrapeptase has been used by a medical professional.
  2. Is it safe? Absolutely, in most cases. To put things into perspective, the amount of people who should refrain from taking serrapeptase is minimal compared to the amount of people who are currently taking aspirin (for a heart condition), and who will eventually experience side effects later.
  3. If you are elderly, the risks and dangers of taking serrapeptase are higher than someone on their thirties or forties.
  4. Serrapeptase is safer than using NSAIDS (Non Steroidal Anti Inflammatory Drugs) long term. (These are pharmaceuticals like ibuprofen)

Can You Use Serrapeptase and Nattokinase Together?

blood pressure monitorYes. And the beauty of it is, that serrapeptase compliments the healing effects of nattokinase, because it halts the production of yet another enzyme, angiotensinogen, which causes high blood pressure and hypertension. The benefits of using both together are untold, because of their complimentary behavior.

If you have constant headaches or migraines, or asthma, IBS, Crohn’s disease or arthritis, then serrapeptase can help you. Seriously, we all know how much work our body does every day, in particular our heart, which beats something like a hundred thousand times per day, pumping over fifteen hundreds gallons of blood around your body.

So you should help the organs in your body to be a healthy as possible for the rest of your long life. I use nattokinase for the purpose of improving my circulation and keeping my blood pressure normal (because I’ve had a DVT, and I also have a family history of heart disease), so I compliment and strengthen it’s healing power with serrapeptase, knowing that inflammation is kept to a minimum and always gets ‘washed away’.

So, if you want an organic enzyme supplement with potent anti-inflammatory healing properties, we really do recommend serrapeptase.

Where Can You Buy Serrapeptase?

I prefer and recommend Good Health Naturally, because of their high dose enteric coated supplements. Their tablets also contain MSM and trace minerals which aid absorption and how much your body actually uses.

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About Andy James

Andy is a health and wellness enthusiast who has a great interest in the cardiovascular system, and more specifically blood circulation. He has suffered with poor circulation for many years, hence why he has to wear a compression stocking on his left leg. But since he was introduced to nattokinase by a colleague, and started taking it on a daily basis his circulation is circulation flows more freely and he has got a lot of pain relief from this incredible little enzyme. You can find out more about Andy on his Google+ profile, where you will find his other sites and projects.


  1. Ann Kirwan says:

    Hello Andy,

    Would you recommend Serrapeptase for my 24-year old son who has been diagnosed with C4 ASIA A spinal injury? Please.

    Thank you.

    • Hi Ann,
      Thank you for your message.

      I trust you understand that I am not a doctor, a mere student and enthusiast of health. I cannot see why your son should not take serrapeptase, however, you should contact your doctor for confirmation.

      I wish your son progress and a speedy return to good health.


  2. HI. andy
    I am fifteen years old, suffering from osteoarthritis, mild varicose veins in my legs,now swelling and pain in the joint of my left foot ,my doctor prescripe serratiopeptidase to reduce swelling and pain ,you think it willbe useful for me,thank you.

    • Hi Nadia,

      Thank you for your message. I would recommend serrapeptase to anyone with your conditions, and as your doctor has prescribed it as well, that is even better.


  3. Judy Ballard says:

    I had bleeding ulcers 7 years ago, I take Nexium every night. If I don’t take Nexium for 2 or 3 nights, I get indigestion. I also have been diagnosed with blockage of the carotid veins and am interested in this supplement for the blockage. What do you think? Should I take it?

    • I would say that you have nothing to lose by trying serrapeptase Judy. It is a really strong, natural blood system aid, and so is nattokinase. You should obviously consult your doctor first before taking any new supplement, but I do think that serrapeptase (or nattokinase, or both) could help you. I say ‘both’ because one compliments the other.

  4. Hi. Just got my order of serrapeptase today and waiting til I have an empty stomach to begin taking it. I have arthritic knees and it was recommended by a friend to try. However, I have been reading about the benefits to the heart. I was diagnosed with Cardiomyopathy a few years back but my heart doctor was amazed how my heart regained strength just by changing to a total plant-based diet. However, I do have left branch block and he said there was no cure to that. I know you are not a doctor, but do you think there might be a chance that serrapeptase could aid in this? Thanks!

    • That is great news Lori. Thanks for the message, by the way. I do think that you could really benefit from a treatment of serrapeptase, but please come back and let us know how you are doing in due course. Good luck. We truly wish you the best with your health.

  5. Diana Reese says:

    Hello, I have Thrombocytopenia and rheumatoid arthritis – is it ok if I take serrapeptase, mangosteen, shilajit and omega 3 all together? It might sound stupid, but I really wanna try all of these for my inflammation and joint pain, I don`t want to start with the methotrexate because of all side effects and think that all this stuff will help me, but please let me know if i can take everything together. Thank you

    • Hi Diana, thanks for your message.

      Please understand that I am not a doctor, so could not give you a definitive answer based on medical practices. However, I do take omega-3 (krill oil is my choice, as it is more easily absorbed by the body and is far superior to fish oils etc), and as you can take nattokinase with serrapeptase, my ‘guess’ (and its only a guess) is that it would be ok.

      I don’t know much about the other two products sorry. If it was me, I would try adding one in at a time and trialling. But be careful not to over do it with blood thinning. Although my circulation is much better, my feet and ankles are hardly swollen any more, I do get nose bleeds from time to time and they take longer to stop now. (that is because of nattokinase and krill oil), but I think you would be safer with serrapeptase and krill oil (or you choice of omega-3 fats), then just add the other products to see if you get more relief.

  6. janice mclaughlin says:

    Hi I was wondering if I could take these I will be turning 53 yrs old in a couple of months and i am having pain in my lower legs so that it could help with cirulation thanks

  7. Hi Andy:
    Have you any knowledge of taking Serrapeptase for non-malignant tumours which appear at various points in the body. Currently the person has a specific radiation treatment to inactivate them and to get relief until the next one appears. This person is married to an MD and has absolutely no knowledge of alternative treatments. Before I suggest taking Serrapeptase it would be helpful for me to have more specific information. (I am not a doctor…just a concerned family member.)

    • The information that I could find for you suggests, similarly to nattokinase, that serrapeptase is already being used to treat non-malignant tumours, and very successfully too. I will email you further information.

  8. bong urbano says:

    i have a lung scar this serrapeptase with enzymes can removed my scar at the lung

  9. Hi Andy,

    If you had an appointment to have some wisdom teeth extracted, or other minor surgery, would you discontinue use of the 2 products beforehand? And if so, how long before?
    Would you resume immediately afterward or wait a few days?


    • Hi Diana,

      The general consensus is to stop taking either product 2 weeks prior to surgery of any kind, then to start immediately back with serrapeptase following surgery to reduce the effects of any inflammation. For nattokinase, at least 7 days or more seems to be recommended as this is the main ‘blood thinner’. However, please confirm this with your doctor before taking any actions.

      Thanks for the message, I hope all goes well.


  10. will this work to remove pollyps…that are causing daily bleeding..non cancerous…im trying serrapertase..recommended by a herbalist…ty

  11. What about a person who was told have emphysema but shows no signs of the disease yet??? He does take supplements but what about your combination??? Any comments are appreciated.

  12. Lauressa says:

    Will the pill help to unclog my blocked Fallopian tubes

  13. Hi Andy I have Tardive Dyskinesia , High blood pressure, and now teeth related matters. My medication i take daily includes 1 x blood pressure tab, 3 xdaily drugs for anxiety, stress, and dyskinesia. Total 11 per day. Botox injections every 3 months. Last year i developed an ulcer on ankle . After op to shrink varicose veins to both legs ulcer healed. Penicillen did not help. presently have abcess under a tooth, gum swollen ,painfull. Have taken 4 brands penicillen and have had it drained surgically twice. Do you think your combo. would help.I am in early 60′ s. Thanks for this site.

    • Hello, thanks for your comment.

      I understand what Tardive Dyskinesia is, but I have no information regarding nattokinase and/or serrapeptase on this. For high blood pressure, yes, the combination could be a great help to you. However, you should consult your doctor regarding taking these enzymes with any blood pressure medication. (please remember that I am not a doctor, merely a health enthusiast with similar problems) I feel you could benefit not only from the blood pressure reducing effects of nattokinase, but also the anti-inflammatory effects of serrapeptase. I wish you the best of health.

  14. HI Andy, I have a problem, I am 20yrs and I found out that I have acute ischaemic infarct involving right internal lapsule& basalgarglia. Can u tell me what can cause that problem, can it be a blood clot to my artery to my heart or brain. can i use Serrapeptase. thank u.

    • Hi Isha, thanks for your comment.

      I really would not like to comment or make any recommendations on your condition because I’ve never heard of it. Why don’t you speak in depth with your doctor about this, it appears to be quite a serious health problem. I do not know if Serrapeptase would help. Sorry I could not be of more help to you.

  15. ANA CRISTINA says:

    Hello I am from Brazi and I heard about this enzyme. I would like to know if it is possible that a patient with Alzheirmer’s disease take it. I also would like to know it there is any problema with the other medicines ( Exelon, for instance).
    Thank you, very much.

  16. Hi Ana,

    Yes, I think someone with Alzheimer’s can take serrapeptase, but to be sure you should always check with a medical professional. I do not know about the other medications, however.

  17. Rick Burton says:

    Can I take both serrapeptase and nattokinase at the same time with the krill oil that I am already taking (on an empty stomach in the am)?

    • Hi Rick, thanks for the message.

      Please be mindful that nattokinase is a powerful natural blood thinner, which can be used and complimented with serrapeptase. However, taking nattokinase with krill oil may bee to much for your blood system and may make your blood too thin. I alternate between nattokinase and krill oil myself, so perhaps try that before taking all three together.

      I hope this helps.

  18. I recently quit smoking marijuanna (6 weeks clean, 14 year habit/addiction ) and quit smoking cigarettes ( 2 years quit, 11 year addiction) . Will taking this enzyme supplement assist my attempts to cleanse my lungs? I’ve taken up cardio exercises, lots of walks/hikes, and drink licorice tea.

    • Hi Claudia, thanks for the message.

      Congratulations on quitting the habits, well done. I imagine you already feel better, health wise, but serrapeptase would also help your lung and bronchial system even further. Keep exercising, eat healthy and you’ll feel a little better, every day.

  19. Rick Burton says:

    Thanks Andy, That was my concern also.

  20. Hi, i am diagnosed recently with atherosclerosis and so called diffuse cardiovascular disease. I also have slightly increased blood pressure, varied from 120/80 trough 140/90.My cardiologist prescribed to me lipitor, baby aspirin and ACE inhibitor. I am only taking baby aspirin for now, as I would like to try everything natural first, having in mind side effects of statins, but also ACE inhibitors. Currently I am taking omega 3, vitamin D, 5-6 grams of vitamin C and 4 grams of lysine per day (Linus Pauling therapy). I am feeling better now. Do you think I should take serrapeptase alone or in combination with nattokinase? If so, which quantities. Please I know you are not doctor, but tell me from your experience.

    • Thanks for your message, I am glad you are on the mend. I would be careful of taking aspirin with nattokinase, omega-3’s or serrapeptase. Aspirin, combined with these naturals may thin your blood too much. Also, the combination of high strength omega-3’s and nattokinase, could cause the same problem.

      However, you could take serrapeptase with krill oil (my preferred source of omega-3 fats) and cycle it with nattokinase. For example, for 6 weeks take serrapeptase and omega-3’s, then serrapeptase and nattokinase for 6 weeks. Either way, I would talk more with your doctor about using any of these with aspirin.

      I hope this was helpful, and your recovery to top health is swift. Andy

  21. Thank you for your answer and time. For how long I should take serrapeptase/nattokinase? Until I clear the arteries or even after?

    • You’re welcome. There is no reason why you can’t take nattokinase as a preventative measure, which is why I take it (cycled with krill oil). As far as I’m aware, the same goes for serrapeptase. There are no side effects to either, unless you take them with prescribed anticoagulants.

  22. Hi Andy, I discovered serrapeptase on the internet a few weeks ago, and I ordered a bottle of serrapeptase which arrived today. Two years ago I had a mild stroke, with lasting consequences. The years before my stroke I had tias almost daily, but the doctor and hospital were not of any help in order to prevent a stroke. Afterwards the hospital subscribed blood thinners and chlolesterol suppressors (statines). I took statines for more than a year, then I read internet info about the huge side effects of statines, stopped taking those statine pills and also stopped with the bloodthinner. Although my arteries are in good condition I want to prevent internal blockage, so I decided to take serrapeptase for a while (empty one bottle, 1 pill a day). I wonder what it will do with the scar tissue in my brain, and also how much time interval makes sense before buying a second bottle of serrapeptase. In order to improve my blood, I eat a grapefruit daily. Thanks Andy, for all the good information on your website.

  23. Hi Koen,

    Sorry to hear of your health problems, I really hope they are behind you now. From everything I’ve researched and now know about serrapeptase and nattokinase, I can only assume that you would benefit from one or both. If you’re not taking blood thinners any more, there is nothing stopping you taking nattokinase as well as serrapeptase. But to make sure, remembering we are not doctors, you should talk to your doctor first.

  24. I’ve been researching Serrapeptase and Nattokinase all day and I’m excited to try them. I have many things this can help with me with. The one answer I am not finding is if these products can be taken long term. Or do you take them for 3 months and then take a break for 1 month? What do you suggest on how long to take them?

    • Hello Dee, thanks for your message.

      Although there is little research done on the long term use of both serrapeptase and nattokinase, there is also no one ‘body’ stating not to take either of them on a long term basis. That being said, I take them intermittently, on a ‘when needed’ basis. I use serrapeptase for longer periods, then swap nattokinase for krill oil, as that is also great for protection from ‘thick’ blood (as well as many other benefits).

  25. nabil Khan says:

    Since May 2009 I have been suffering with chest pain. All tests have shown it is not cardiac related. Endoscopy was clear, lungs clear. But the pain comes when bending forward with full stomach, walking faster than normal ( worse after food) cold weather, or nay sudden stress. Not been able to swim more than 50 meters without stopping and resting for 5 minutes between. I have stared taking Serra enzyme 250,000. iu twice a day since one month and I have begun feeling a bit of change in the pattern of my painful condition. My question is this. ” Can it really be doing some healing or is it my imagination, and is it too early yet for complete healing and thirdly will it ever cure me completely”. I shall be most grateful to receive your comment per my email above. I am prepared to pay you for your opinion. Sincerely Nabil

    • Hi Nabil, thanks for your message.

      Yes, I believe that the serrapeptase is doing it’s job, which is great to hear. I think if there was ever any natural product that could clear up an inflammation like the one you describe, serrapeptase is the one that could do it.

  26. Annette says:

    Can serrapeptase help reduce gotire

    • Yes, I believe it could help you. Plus, you may want to try taking maca also, as this can help to regulate the thyroid as far as I am aware. I have not tried it myself yet, but I have heard great things about Maca. It is another natural product, which is quite powerful. You can read more about it here.

  27. michelle says:

    Hi Andy,
    Can I take serrapeptase if we’re trying to conceive? I also have a fibroid. TIA

  28. Hi Andy,
    I hope you are doing well. My question involves my extremities. When I perform any physical activity like mowing the lawn or taking a brisk walk, my legs and arms will get sore. My extremities also have a tendency to get cold very easily, especially when I am in a cooler environment. It seems my body has a lot of inflammation which is chronic in my opinion. From my research the inflammation may be attributed to a leaky gut. I know you are not a doctor, but from your experience and knowledge would taking serrapeptase and nattokinase help with my health issues, primarily the soreness in my extremities? Also, how much per day should I be taking? Currently I am taking curcumin and ginger to help with my inflammation, but not too much relief. Even anti-inflammatories don’t seem to help much. Any comments are appreciated. Thanks.

    • Hi Eddie, thanks for your message.

      Firstly, I am sorry to hear of your troubles and I hope you find relief very quickly. I am sure that serrapeptase will help you in every area, it’s not a ‘targetted’ substance, so should help all over your body. As for dosage, 80,000iu is the normal dosage (GoodHealthUSA), but in the past I have doubled it, but only for a short period, when I’ve had problems.

      The same for nattokinase, double dosage, but only for a week or so, then back to the recommended dose. Nattokinase works really well with serrapeptase, but I am not sure you would want to take curcumin as as well. And I would also say not to take anti-inflammatory ‘drugs’ at the same time, you don’t want your blood becoming too thin!

      I hope this has been helpful Eddie, please let me know if I can help further, just come back anytime.


  29. Hi Andy,
    Thank you for the quick reply! For the nattokinase, is that 80,000iu daily. Should the doses be divided into two or three doses throughout the day?
    On another issue, I had been taking calcium supplements daily for years, I was taking 1,000mg daily plus almond milk that was fortified with calcium. During this time my Vitamin D3 levels were low and I always wasn’t getting any Vitamin K. I stopped supplementing about eight months ago with my only calcium intake from veggies, an occasional greek yogurt or fortified almond milk. From what I’ve read, it’s a possibility that I may have caused calcification to my arteries and other areas of my body, which may be the reason for the inflammation in my body. My question is, will the serrapeptase or nattokinase help reversing the existing calcification that my possibly exist? Your comments are appreciated. Thanks in advance.

    • 80,000iu was for serrapeptase, nattokinase recommended dosage is 2,000fu which is one capsule. For the calcification, I am unsure of a complete reversal, but the combination should definitely help (from what I’ve read, and understand). Regarding calcium, if you still require supplementation, you may want to look into magnesium oil. If you didn’t know, it is absorbed via the skin and provides a lot of healing power, including calcium. I generally use it when I get sore joints, as I am in the gym most days. It alleviates a lot of pain too. If you want more information, I can email you, just let me know.

  30. I was doing some internet research on reversing calcification and found a study done in the Netherlands with results that supplementing with vitamin K2 was shown to reverse calcification. What’s your opinion on this and can I supplement with K2 while taking the Serrapeptase and Nattokinase? Thanks

    • From what I’ve read about K2, I think you could also benefit. But I would be careful about using any more blood thinners at the same time. Blood which is ‘too thin’ can be very dangerous.

  31. Thanks for the reply Andy.

    Does Vitamin K2 thin the blood?

    • I don’t know too much about k2 (but I’m going to research it now!), but yes it does have anti-coagulant properties from what I have read so far.

  32. Thanks again Andy. Have a great week!

  33. nana akua says:

    Please I hv batholin cyst n inflammation on my joints do you think Serrapeptase can help me though mine arrived today? And can it be taken with Iodine supplement? Thank You

  34. hello can this product heal eye floaters?


    • Hi Paul, thanks for the message.

      Eye floaters are a very complex condition, as far as I know, which requires quite an ‘involved’ solution. Although, you could try taking 4 doses per day (250,000iu per dose), plus you should eliminate sugars/carbohydrates from your diet at the same time. If my memory serves me correct, from my research, this should help.

  35. I take 80,000 iu’s twice a day. It has many claims to it but what I know it treats very well it inflammation pain. Lymph in the chest area, heartburn like symptoms, or bronchitis.

    It works better than anything I have tried not really sure why. I think it breaks down dead tissue/scar tissue that causes the pain instead of acting of the inflammation itself which makes it the best way to go about it. So I think it would be ideal for recovery on direct injuries/some kinds of chronic pain for most people.

    The only side effect I get from it is almost immediate hunger because 30 minutes after taking it I’d better have food ready to eat because my stomach is voicing demands. So if your prone to overeat anyways watch taking it several times a day or daily because if your anything like me 1 pill will equal 1 meal to be had. If you under eat try it because it really does press the hunger button.

  36. Hello! 3 questions: I have cataracts developing and also uterine fibroids. Will serrapeptase help clear those conditions? Do any supplements interfere with the action of serrapeptase (for example zinc and the b vitamins)? And is it safe to give serrapeptase to my 12 lb. diabetic dog who also has cataracts? Thak you for this service.

    • Hi Kathi, yes to all three questions. Regarding your dog, I’ve recently had correspondance via email with a lady who cured her dog of a sinus cavity and swelling. The only thing I am not sure of is the diabetes factor, but serrapeptase can help humans with diabetes, so I do think it would help your pet.

  37. Hi Andy,
    I am suffering from foot condition called morton’s neuroma for almost 3 years now. The pain is so excruciating that I am unable to walk or stand anymore. It was initially in my one foot, now the other foot also having similar symptoms. I have everything done that is recommended from resting, icing, physical therapy, cortisone and ethanol injections in both of my feet in series of 2 and 10 respectively. But it’s all temporary relief. I have also taken SerraGold in the past bottle of 60 caps, I took 1 cap twice day, it did not help.
    Would you please guide me how I can take this enzyme again and what would be the recommended dose, strength, and for how long I should take before seeing the results? Do different brands work differently in therapy?
    I really don’t want to go for surgery as the success rate is very less and the neuroma reoccurs.
    Thanks for your help.

    • Hi Sonia, thanks for your message.

      The maxiumum dose is recommended at 80,000iu x 3 capsules per day. For a serious problem like this, you may need this. I don’t know much about the condition sorry, but if it is something than can be treated, then cured, you only need such a high dose until you are happy. The brand I use (for my own supplements is Good Health Naturally), if they are the same iu’s as other brands, they should work the same way. You may also want to look at using nattokinase, cycling with serrapeptase as one compliments the other.


      • Thank you for your reply Andy, sorry for getting back late. I am going to try the Good Health Naturally brand and going to take now 80,000IU x 3 daily along with Nattokinase. Is there any specific dose and strength for Nattokinase that I should be taking?

        Thank you again.

        • Hi again Sonia. Just follow the recommended dose of nattokinase, as you’re taking it with serrapeptase. Although you can take more, it may ‘thin’ your blood, preventing coagulation, so be mindful of this.

  38. Hi Andy,
    I have eye floaters, high blood pressure and cholesterol. Would serrapeptase help? What would be the dose to take on daily basis? And regarding eye floaters, what is your recommended dose per day? Is it 80 000iu per dose 3x a day?

  39. Hi Noor, thanks for the contact.

    Regarding ‘eye floaters’, please see Pauls comment above.

    Regarding high blood pressure and cholesterol, yes, serrapeptase would help. You may want to consider taking nattokinase too (or even by itself), just speaking from personal experience. Nattokinase worked wonders for my blood system.

  40. Hi,
    For some time now, I’ve been having poor circulation due to macrocytosis (none of my doctors can figure out WHY I have macrocytosis), AND I’ve also been having erratic bowel movements (have already been found NEGATIVE for different gastro diseases, AND for food allergies)…I recently started taking serrapeptase (without any bad “other ingredients”), and my gastro symptoms got worse (btw, I’m NOT elderly)…
    To sum up, I NEED serrapeptase for my circulation, but I can’t seem to tolerate it…would nattokinase (or some other good probiotic supplement) help me tolerate it? Or would taking an enzyme BLEND with the serrapaptease do? (Btw, I ALREADY try to consume as much organic and fermented foods/drinks as possible.) THANK YOU VERY MUCH FOR YOUR RESPONSE.

    • Hi Liz, thanks for your comment.

      I am sorry to hear of your conditions – my first idea is that perhaps you are ingesting too much ‘fermented/enzyme’ based foods. Your body may tolerate the serrapeptase on its own, but perhaps the elements in the probiotic foods are not mixing well. You could try taking ‘Blockbuster all clear’, which is a blend of serrapeptase and nattokinase, but I think (although probiotic/organic food is the healthiest option), maybe cut down on the probiotic foods for a while and see if your tolerance level for the serrapeptase levels out.

  41. Does serrapeptase reverse atherosclerosis or in any way reduce the buildup? Thanks

  42. Thanks Andy. I was researching decalcification of the arteries and read that drinking apple cider vinegar in water with meals will helps remove the calcium buildup. I know it works wonders on cleaning hard water buildup and lime deposits so I wonder if this might actually help. What’s your opinion on this Andy?

  43. Hi,
    Would you suggest serrapeptase for bilateral fallopian fimbrial blockage due to history of tuberculosis. ?
    Have taken treatment for 1 year.
    I have undergone hsg and laparoscopy. In laparoscopy it was revealed that some calcified material was also attached with tubes.
    What can I do to unblock them naturally.
    I have already failed 4 ivf transfers and am desperate to conceive. Please help.
    Thanks in advance.

    • Hi GSN, thanks for your message.

      I don’t have anything in my research for your condition specifically, but serrapeptase does break down calcified materials and dead cells in the body.

  44. Hi Andy,
    Does one have to wait 30 minutes after taking serrapeptase before eating or waiting two hours after eating before you take it? Also, does this also apply to nattokinase? Thanks

  45. Will serrapeptase help with fibroid? If yes how much Shd I take and Shd I take it in an empty stomach? Fm your site, I understand nattokinase will help with fibroid, can you pls tell me the dosage & should I take it in an empty stomach first thing in the morning?? Is it better to take both for my fibroid or just nattokinase is fine. Many Tks

    • Yes, take nattokinase and serrapeptase together, on an empty stomach or 30 minutes before eating. Blockbuster Allclear may be your best option, 3 capsules x 3 times a day. Plus, you may want to also consider taking Curcumin as this will also help shrink the fibroids.

      Also, consider eliminating all things containing sugar/glucose from your diet, and follow as natural a diet as you can. A ‘natural’ diet will work with the supplements, helping to treat your problem quicker.

  46. ian underwood says:

    My wife and I have been taking these for 6 months and can attest to the benefits but we will be taking a long haul flight and wondered would the serrapeptase help with swelling legs on the plane !

    • Hi Ian, thanks for the message. Yes, serrapeptase will help, but you may also like to read about nattokinase, as this is a better blood thinner, and both of them can be taken together offering greater protection. Keeping my blood ‘thin’ is highly important to me, as it is I imagine for your wife, which is how I initially discovered nattokinase. It made a huge difference to my life.

      I hope the trip goes well, for you and your wife.

  47. Catherine b says:

    Hi there

    I’ve had swelling and pain in my heel for a year and the doctors have been a bit puzzled with my case but they believe I have a small piece of nexrotic/infected bone in the heel bone, causing the swelling. They suggest a biopsy to test the area and confirm their suspicions then an operation to remove it. I’m only 26 and would like to avoid the op if I can as its in a tricky spot and it’s going to be months of healing time.

    My naturopath thinks serrapeptase and diatrom Earth (silica) could break this down over time naturally. I have been on blockbuster all clear for three weeks taking 3 capsules 3 x a day but had no relief. So For a week I’ve been taking 4 capsules of the 250,000iu 3 x a day.

    I would love to know if you think this might help my issue and if so how long you would expect until I start to feel better. I’m getting married in January and desperately want to walk down the aisle pain free!!

    Thanks so much.


    • Hi Catherine, thanks for your message. I have not come across this before, so could not say exactly. However, as there are no real side effects to serrapeptase, it is definitely worth trying before surgery I think. Also, you may like to try additional anti-inflammatories like curcumin and/or astaxanthin, which can be found in krill oil or in capsules by itself. Good luck for your wedding, I really hope you can walk down the aisle pain free.


  48. Chantelle says:

    Hi, I have been suffering with a bartholin gland cyst for about 12 years now. It abscessed a week ago and i took (am taking) antibiotics for it. The pain of the infection is gone but the fluid remains. I started taking serapeptase today in a last ditch effort to be rid of this thing! Do you think it will be successful? Any idea on when I should expect results? I only ask because my next step would be a surgical procedure that I am avoiding at all costs and I am unsure of a time frame. I have the 120,000ui. I took one this morning on empty stomach and another just now. Is this an ok dosage?

    • Hi Chantelle, sorry to hear of your conditions. I didn’t have any knowledge on bartholin gland cysts, but after a search on some medical sites, I see that serrapeptase is really helping people with the condition. As for dosage, I believe you could take double that dose, as Good Health Naturally have just release a 250,000iu capsule. If it is any different to that, I will leave a further message hear for you in the next 24 hours.

  49. chantelle says:

    is there any time frame i could be looking at for a cyst? I know it is different for everyone but is there a general idea for something such as a cyst? My first day taking serapeptase was nice. It eased my discomfort almost immediately but today it feels like a pinchy stinging feeling… im wondering if it is possible to feel the breakdown or if im just going out of my mind with this stupid thing… Im going to double up on my dosage unless u state otherwise and *fingers crossed be rid of this very soon! Not enjoying the idea of another surgery!

  50. Hi

    I was wondering if you think its OK to take Serrapeptase along with Rhiodola Root and 5HTP? I have Serrapeptase twice a day on an empty stomach and Rhodiola at home once eaten, and 5HTP with lunch. I suffer from chronic tension headaches and muscle spasms which I believe could made worse by anxiety and sleepless nights which I suffer from for some reason.

    Thanks for your help.


    • Hi Cat,

      I don’t have anything in my research for Rhiodola root or 5HTP, but I know that the former may increase blood pressure slightly in some people, which works against serrapeptase (which helps to lower BP). So I imagine the negative would be cancelled out by serrapeptase, but I could not confirm this. The root is also a blood thinner to some degree, which may have a negative interaction with serrapeptase, so you should be careful if using them together. And definitely don’t use either of these with any prescribed blood thinning medication.

      As far as I know, 5htp is wonderful for the brain, increasing serotonin and alleviating symptoms of depression and anxiety, but as for any interactions, I really don’t know. I could not find anything negative on this.


  51. Hi andy,
    I’ve been suffering from ibs, constipation. Will serrapeptase and nattokinase help me.

    • Serrapeptase would help with irritable bowel syndrome, try the Serranol product on our recommended products page. The combination of ingredients, including curcumin and Ecklonia Cava and vitamin D should alleviate your symptoms. Plus, you may want to take a digestive aid as well, but make sure it is a quality products.

  52. Hi Andy..I have been taking Nattokinase + Serrpeptase for 1 month order from Matt..3000fu Serr…2000/Umg I suffer with Lymphema….do you think it would benefit me.

    • Hi Bridgett,

      Sorry, I don’t have anything in my research for your condition, but if Lymphema is an inflammation of some kind, even cancerous, then yes I believe they could help you.

  53. Gillianmunster says:

    Hi Andy, Im looking to not only start myself on the serrapeptase, but I would also like to put our animals with certain joint and circulation problems on some, however I’m really not sure whether or not they should be on the same dosage as humans as I will be giving it to the 2 horses as well as our cat. Can you help me with this?

    • Hi Gillian, thanks for the message.

      If you click through any of the images to the Good Health site, then use their search function, you will find s’errapeptase for pets’. They provide dosages for dogs and horses, cats too.

  54. Hi Andy,
    Yesterday I was diagnosed with a 4cm cyst on my right ovary, a small uterine fibroid (also enlarged uterus, I guess due to the fibroid) and a uterine polyp. Dr is using the “watch and see” method; but I’d like to be more holistically active so when I go back they are all gone or at least significantly reduced. I’ve read this entire page, but what would you recommend for me and please specify dosage recommendations as well?
    1. Serrapeptase and Krill Oil
    2. Blockbuster All Clear and Krill Oil
    3. Blockbuster All Clear
    4. Other?

    Thank you,

    • Hi Windy,

      A combination of nattokinase and serrapeptase, I think would help you. So, BlockbusterAllclear – 3 x 3 times daily. Avoid food for thirty minutes after taking them. If you were to take krill oil, don’t take nattokinase as the combination might ‘thin’ your blood too much, and affecting blood coagulation, which might become dangerous. I have taken krill oil with serrapeptase, but not nattokinase. You may also like to add in curcumin 3 times daily, as this is a natural antioxidant also.

      If you wanted to take a higher dose of serrapeptase, you could take the 250,000iu and take nattokinase as well, which is a good combination.

      Good luck, please come back and let us know how you get on with your healing.

  55. Hi Andy,
    I have symptoms of DVT in both legs. I have been taking Nattokinase, fish oil, and Vitamin E and I feel like it has helped. I recently ordered some Serapeptase 120,000iu. What doseage would you recommend in combination with Nattokinase, fish oil, and Vitamin E?

    • Hi Katsuya, thanks for your contact. You have similar problems to me. Are you wearing compression stockings too? I find they help, but are not a cure! As you are already taking fish oil, on top of nattokinase, I would recommend following the recommended dosage. Be careful your blood does not ‘thin’ too much, it might cause you reverse problems in the future. If you do start having problems, its probably best to stop taking the fish oils.

  56. Hi Andy,
    Thanks for getting back to me. I do have compression stockings, but I don’t really wear them. I occasionally have pain in my leg, but its not excruciating or anything. I’ve been taking Nattokinase and fish oil for about a month, but I didn’t start feeling improvement until after I started taking Vitamin E to go along with them. I also just started taking Pine Bark Extract a few days ago and the swelling on my leg seems to have gone down a bit.
    If I started taking serapeptase, do you think it’ll be dangerous to take all the other supplement with it?

  57. Thank you so much for your reply, Andy. Quick clarification, so Blockbuster All Clear now comes in two formulas a 40,000 IU from and a 80,000 IU from; for both, a serving is 2 tablets. Are you recommending me to take a total of 250,000 IU of Blockbuster All clear per day OR 250,000 IU in each 3×3 serving? That part confused me a bit.

    Thank you so much, and I will definitely provide an update after my follow-up appointment.

    • Yes, take 3 capsules per serving (9 per day), relating to Good Health product. If you use another product, use that as a guide to figure your dose. You’re welcome, please come back anytime.

  58. Kael elle says:

    Hi Dr. Andy James, I was wondering if it could help cure bartholin cysts. I’ve had one drained 5months ago and it came back. I’ve read that many women with BC lives by it. Just wanted to know your thoughts about it. I had just bought a bottle of Serrapeptase and today is my 2nd day taking it. I’m taking 3 pills a day due to the imflammed cyst and for the pain. Please let me know what you think about it. Will it work? Thanks.

  59. Hi Andy,

    I suffer from esophigitus and gastritis and react badly to acid suppressing medication so am looking for a natural alternative. I currently take Pepzin GI but was looking for something else to help with the inflammation. I see that you have outlined some gastrointestinal disturbances in reaction to the enzyme, do you think it would be beneficial to this condition? Have you any experience with people that have used Serrapeptase for Gastritis and Esophigitus? My doctor had never heard of the enzyme, and is only happy to prescribe PPI’s or H2 Acid drugs, which are well known to be bad for you and dont help me.

    Thanks a lot for your time and information provided through your blog.

    James R

    • Hi James, thanks for the question. I have recently read about a few people who took serrapeptase when they already had stomach upset. Their experience was not positive, so I would not recommend it. Have you tried natural/alternative gastro treatments? Good Health USA have something called ‘Gastro Enzyme’, which I hear good things about. Just click any image on this site, once you are on their site just use their search box.

      Unfortunately, most doctors have never heard of serrapeptase! Good with your self healing.

  60. Can I take serrapeptase right after laparoscopic surgery?

  61. I forgot to mention that I did the surgery because I had blocked tubes causing by scars tissues so I am trying to prevent them from build up again after the laparoscopic surgery. I am currently 15 days of recovery, could I start taking serrapeptase now or I have to wait for a few more weeks? Thanks

  62. stephanie conner says:

    Would serrapeptase help with stretchmarks and scars? I also fell in Dec 2014 and banged my right knee pretty bad. Would it eat up any swollen scar tissue?

  63. Are you familiar with Pulmonary Hypertension? I am taking nattokinase to thin my blood, and considering adding serrapeptase to reverse artery stiffening between the heart and lung. This, along with a mostly anti inflammatory diet, and daily walking.

  64. Hello Andy,

    I have fibrotic components on my right upper lobe due to ptb. Can my lung scar fade by using serrapeptase? I just finished my treatment for ptb can i use serrapeptase to help clear out my lung scar? And may i know what dosage can i take? My weight is 53kgs. Please help, thank you very much and God bless.


    • Hi Krystal, thanks for your message. I believe serrapeptase would help with lung scarring. I would not like to suggest a dosage, but Good Health Naturally now have a stronger dose available (which I am currently taking), which is 250,000iu (you can find this stronger dose on our ‘recommended nattokinase products’ page at the top of this page.

      Wishing you improved health.

  65. I bought a serrapeptase 40,000IU , because I had a bartholin cyst. The brand that I bought is “Amazing Nutrition” . As per suggested use, 1 capsule daily preferably with a meal. However , as I researched, it should be taken with an empty stomach. Just wanna ask, which is the best effective way?

  66. I have been suffering from a bartholin cyst for about 2 to 3 years now. My first bc turned into an abscess and was drained but came right back. My second one turned into an abscess and I began using homeopathic pellets such as Sabina and silica. Those barely worked. Then came back my third one. To prevent it turning into abscess #3, will serrapeptase help/work?!

  67. hi wath is the diference of units or spu i have serrapeptase 250000 spu and any recomendation for me i seffer acid reflux and reumatide arthritis thank you!

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